Which infants can be included?

  • very preterm infants with a gestational age < 32 weeks
  • very low birth weight infants < 1500g
  • intraventricular haemorrhage (grade II - IV)
  • chronological age < 8 days

Which infants must be excluded?

  • genetically defined syndromes
  • severe congenital malformation adversely affecting life expectancy or neurodevelopment
  • admitted a priori for palliative care
  • unlikely to participate at 5-year follow-up examination